Title : Disposition and metabolism of codeine after single and chronic doses in one poor and seven extensive metabolisers.

Pub. Date : 1991 Apr

PMID : 2049245






1 Functional Relationships(s)
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1 After the single dose, the partial clearance to morphine was 137 +/- 31 ml min-1 in the seven extensive metabolisers and 8 ml min-1 in the poor metaboliser; to norcodeine the values were 103 +/- 33 ml min-1 and 90 ml min-1; to codeine-6-glucuronide the values were 914 +/- 129 ml min-1 and 971 ml min-1; and intrinsic clearance was 1568 +/- 103 ml min-1 and 1450 ml min-1. Morphine CD59 molecule (CD59 blood group) Homo sapiens