Title : Isolation from bovine brain and structural characterization of HBNF, a heparin-binding neurotrophic factor.

Pub. Date : 1991

PMID : 2049182






1 Functional Relationships(s)
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1 A heparin-binding protein with neurotrophic activity for perinatal rat neurons, termed HBNF, was purified to homogeneity from bovine brain utilizing pH 4.5 extraction, ammonium sulfate precipitation, cation exchange and heparin-Sepharose affinity chromatographies, and reverse phase HPLC. Heparin pleiotrophin Rattus norvegicus