Title : CTLA4 CT60 single-nucleotide polymorphism is associated with Slovenian inflammatory bowel disease patients and regulates expression of CTLA4 isoforms.

Pub. Date : 2010 Oct

PMID : 20491567






7 Functional Relationships(s)
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1 We found lower expression of the CTLA4 gene in blood lymphocytes from IBD patients compared to control subjects (p < 0.001) and higher CTLA4 expression in biopsies taken from inflamed part of the colon compared to noninflamed part of the colon (p = 0.021). Adenosine Monophosphate cytotoxic T-lymphocyte associated protein 4 Homo sapiens
2 We found lower expression of the CTLA4 gene in blood lymphocytes from IBD patients compared to control subjects (p < 0.001) and higher CTLA4 expression in biopsies taken from inflamed part of the colon compared to noninflamed part of the colon (p = 0.021). Adenosine Monophosphate cytotoxic T-lymphocyte associated protein 4 Homo sapiens
3 We found lower expression of the CTLA4 gene in blood lymphocytes from IBD patients compared to control subjects (p < 0.001) and higher CTLA4 expression in biopsies taken from inflamed part of the colon compared to noninflamed part of the colon (p = 0.021). Adenosine Monophosphate cytotoxic T-lymphocyte associated protein 4 Homo sapiens
4 We found lower expression of the CTLA4 gene in blood lymphocytes from IBD patients compared to control subjects (p < 0.001) and higher CTLA4 expression in biopsies taken from inflamed part of the colon compared to noninflamed part of the colon (p = 0.021). Adenosine Monophosphate cytotoxic T-lymphocyte associated protein 4 Homo sapiens
5 We found lower expression of the CTLA4 gene in blood lymphocytes from IBD patients compared to control subjects (p < 0.001) and higher CTLA4 expression in biopsies taken from inflamed part of the colon compared to noninflamed part of the colon (p = 0.021). Adenosine Monophosphate cytotoxic T-lymphocyte associated protein 4 Homo sapiens
6 We found lower expression of soluble CTLA4 isoform than membrane-bound full-length isoform in peripheral blood lymphocytes from IBD patients compared to control subjects (p = 0.010) and in lymphocytes from IBD patients with CTLA4 CT60 GG genotype compared to IBD patients with AA genotype (p = 0.034). Adenosine Monophosphate cytotoxic T-lymphocyte associated protein 4 Homo sapiens
7 We found lower expression of soluble CTLA4 isoform than membrane-bound full-length isoform in peripheral blood lymphocytes from IBD patients compared to control subjects (p = 0.010) and in lymphocytes from IBD patients with CTLA4 CT60 GG genotype compared to IBD patients with AA genotype (p = 0.034). Adenosine Monophosphate cytotoxic T-lymphocyte associated protein 4 Homo sapiens