Pub. Date : 2010 Apr 23
PMID : 20490331
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sorafenib downregulates ERK/Akt and STAT3 survival pathways and induces apoptosis in a human neuroblastoma cell line. | Sorafenib | signal transducer and activator of transcription 3 | Homo sapiens |
| 2 | Sorafenib is a multikinase inhibitor that also inhibits STAT3 signaling and induces apoptosis. | Sorafenib | signal transducer and activator of transcription 3 | Homo sapiens |
| 3 | Western blots showed a decrease of p-ERK1/2, p-Akt1/2/3, p-STAT3, and p-AMPKalpha expression levels in various sorafenib treatment groups. | Sorafenib | signal transducer and activator of transcription 3 | Homo sapiens |
| 4 | Our results indicate that sorafenib significantly decreased cell viability and increased apoptosis in human neuroblastoma cell line in association with down-regulation of p-ERK1/2, p-Akt, p-STAT3 survival pathways. | Sorafenib | signal transducer and activator of transcription 3 | Homo sapiens |