Title : Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice.

Pub. Date : 2010 Jul

PMID : 20484465






2 Functional Relationships(s)
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1 Pharmacological or molecular intervention of protein kinase A (PKA) or ERK1/2 completely abolished genistein-stimulated beta-cell proliferation, suggesting that both molecules are essential for genistein action. Genistein mitogen-activated protein kinase 3 Mus musculus
2 These results demonstrate that genistein may be a natural antidiabetic agent by directly modulating pancreatic beta-cell function via activation of the cAMP/PKA-dependent ERK1/2 signaling pathway. Genistein mitogen-activated protein kinase 3 Mus musculus