Title : Inhibition of hypoxia-inducible factor-1alpha (HIF-1alpha) protein synthesis by DNA damage inducing agents.

Pub. Date : 2010 May 7

PMID : 20479887






2 Functional Relationships(s)
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1 Camptothecin is a reported inhibitor of HIF-1alpha translation, while mitomycin C has been reported to induce p53-dependent HIF-1alpha degradation. Mitomycin tumor protein p53 Homo sapiens
2 In this study we demonstrate that the inhibitory effect of mitomycin C on HIF-1alpha protein expression is not dependent on p53 and protein degradation, but also involves HIF-1alpha translational regulation. Mitomycin tumor protein p53 Homo sapiens