Title : Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6.

Pub. Date : 2010 Jul 16

PMID : 20478313






1 Functional Relationships(s)
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1 Although the crystal structures of active JAK1 and JAK2 kinase domains have been reported recently with the clinical compound CP-690550, the structures of both TYK2 and JAK3 with CP-690550 have remained outstanding. tofacitinib tyrosine kinase 2 Homo sapiens