Title : Autoregulation of phospholipase D activity is coupled to selective induction of phospholipase D1 expression to promote invasion of breast cancer cells.

Pub. Date : 2011 Feb 15

PMID : 20473892






2 Functional Relationships(s)
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1 Phosphatidic acid, the product of PLD activity, leads to an increase in the Ras-ERK/PI3K-NFkappaB signaling cascade and enhances binding of NFkappaB to the PLD1 promoter, consequently inducing selective PLD1 expression in SK-BR3 breast cancer cells. Phosphatidic Acids phospholipase D1 Homo sapiens
2 Phosphatidic acid, the product of PLD activity, leads to an increase in the Ras-ERK/PI3K-NFkappaB signaling cascade and enhances binding of NFkappaB to the PLD1 promoter, consequently inducing selective PLD1 expression in SK-BR3 breast cancer cells. Phosphatidic Acids phospholipase D1 Homo sapiens