Title : A role of phosphodiesterase-3B pathway in mediating leptin action on proopiomelanocortin and neurotensin neurons in the hypothalamus.

Pub. Date : 2010 Jul 19

PMID : 20471454






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 To this end, we assessed the effect of cilostamide on leptin-induced POMC and NT gene expression in the rat hypothalamus. cilostamide neurotensin Rattus norvegicus
2 Results showed that while central injection of leptin significantly increased both POMC and NT mRNA levels in the medial basal hypothalamus, cilostamide completely reversed this effect of leptin suggesting a PDE3B-activation dependent induction of POMC and NT gene expression by leptin. cilostamide neurotensin Rattus norvegicus