Title : Agonism with the omega-3 fatty acids alpha-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor.

Pub. Date : 2010 Jun 11

PMID : 20471368






2 Functional Relationships(s)
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1 The newly discovered G protein-coupled receptor GPR120 has recently been shown to stimulate secretion of the gut hormones glucagon-like peptide-1 and cholecystokinin upon binding of free fatty acids, thrusting it to the forefront of drug discovery efforts for treatment of type 2 diabetes as well as satiety and obesity. Fatty Acids, Nonesterified free fatty acid receptor 4 Homo sapiens
2 These are the first results which demonstrate specific phosphorylation of GPR120 isoforms upon agonism by free fatty acids and the first which distinguish the phosphorylation profiles of the two GPR120 isoforms. Fatty Acids, Nonesterified free fatty acid receptor 4 Homo sapiens