Title : Simvastatin enhances irinotecan-induced apoptosis in human non-small cell lung cancer cells by inhibition of proteasome activity.

Pub. Date : 2011 Oct

PMID : 20467885






2 Functional Relationships(s)
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1 Simvastatin, a potent inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) is known to stimulate apoptotic cell death and induce cell cycle arrest through inhibition of proteasome. Simvastatin 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens
2 Simvastatin, a potent inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) is known to stimulate apoptotic cell death and induce cell cycle arrest through inhibition of proteasome. Simvastatin 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens