Title : Evidence for and possible mechanisms of non-genotoxic carcinogenesis in the rodent thyroid.

Pub. Date : 1991 Jun

PMID : 2046691






1 Functional Relationships(s)
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1 The sequence of the cell biological changes involved is not fully understood, but it has been shown that IGF-1 is a necessary co-factor for the growth-stimulating effect of TSH in the normal cell, and that autocrine production of IGF-1 is a feature of spontaneous thyroid adenomas. Thyrotropin insulin like growth factor 1 Homo sapiens