Title : Evaluation of phosphinates as potential pretreatments for nerve agents.

Pub. Date : 1991

PMID : 2046471






3 Functional Relationships(s)
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1 To assess the utility of phosphinates as pretreatments against nerve agents, experiments were conducted to determine whether oximes can reactivate phosphinate-inhibited guinea pig acetylcholinesterase (AChE) and whether the toxicity of phosphinates is reduced by treatment with atropine and/or oxime. Oximes acetylcholinesterase Cavia porcellus
2 To assess the utility of phosphinates as pretreatments against nerve agents, experiments were conducted to determine whether oximes can reactivate phosphinate-inhibited guinea pig acetylcholinesterase (AChE) and whether the toxicity of phosphinates is reduced by treatment with atropine and/or oxime. Oximes acetylcholinesterase Cavia porcellus
3 Both oximes significantly reactivated MPP- or CMPP-inhibited AChE; however, HI-6 was the better reactivator in both cases. Oximes acetylcholinesterase Cavia porcellus