Title : Unregulated ARF6 activation in epithelial cysts generates hyperactive signaling endosomes and disrupts morphogenesis.

Pub. Date : 2010 Jul 1

PMID : 20462959






1 Functional Relationships(s)
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1 We describe a signaling axis involving sustained activation of the GTP-binding protein, ARF6, that provokes dramatic changes in the organization of epithelial cysts, reminiscent of tumorigenic glandular phenotypes. Guanosine Triphosphate ADP ribosylation factor 6 Homo sapiens