Title : Dynamic changes in the TRPA1 selectivity filter lead to progressive but reversible pore dilation.

Pub. Date : 2010 Jun

PMID : 20457836






1 Functional Relationships(s)
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1 We found that agonist stimulation of TRPA1, along with other members of the TRP family (TRPV1-4 and TRPM8), can induce the appearance of a large pore permeable to large organic cations such as Yo-Pro (YP) and N-methyl-d-glucamine, in an agonist and divalent cation-dependent manner. Meglumine transient receptor potential cation channel subfamily A member 1 Homo sapiens