Pub. Date : 2010 Aug
PMID : 20448244
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AMPK attenuates bupivacaine-induced neurotoxicity. | Bupivacaine | protein kinase AMP-activated catalytic subunit alpha 2 | Rattus norvegicus |
| 2 | We hypothesized that AMPK may be cytoprotective in bupivacaine-treated Schwann cells. | Bupivacaine | protein kinase AMP-activated catalytic subunit alpha 2 | Rattus norvegicus |
| 3 | The expression of phosphorylated AMPK was compared after bupivacaine treatment. | Bupivacaine | protein kinase AMP-activated catalytic subunit alpha 2 | Rattus norvegicus |
| 4 | Bupivacaine induced cell death in a time- and dose- [50% lethal dose (LD(50)) = 316 microM] dependent manner, and increased expression of phosphorylated AMPK after bupivacaine treatment. | Bupivacaine | protein kinase AMP-activated catalytic subunit alpha 2 | Rattus norvegicus |
| 5 | Bupivacaine induced cell death in a time- and dose- [50% lethal dose (LD(50)) = 316 microM] dependent manner, and increased expression of phosphorylated AMPK after bupivacaine treatment. | Bupivacaine | protein kinase AMP-activated catalytic subunit alpha 2 | Rattus norvegicus |
| 6 | Bupivacaine-induced cytotoxicity was attenuated by AICAR (an AMPK activator), whereas compound C (an AMPK inhibitor) enhanced it. | Bupivacaine | protein kinase AMP-activated catalytic subunit alpha 2 | Rattus norvegicus |
| 7 | Our results suggest that the AMPK pathway may protect Schwann cells from bupivacaine-induced cytotoxicity. | Bupivacaine | protein kinase AMP-activated catalytic subunit alpha 2 | Rattus norvegicus |