Title : Human chorionic gonadotropin up-regulates expression of myeloid cell leukemia-1 protein in human granulosa-lutein cells: implication of corpus luteum rescue and ovarian hyperstimulation syndrome.

Pub. Date : 2010 Aug

PMID : 20444920






2 Functional Relationships(s)
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1 hCG induced Mcl-1 expression through the LH/hCG receptor, adenylate cyclase, protein kinase A, and cAMP response element-binding protein signal pathway. Cyclic AMP hypertrichosis 2 (generalised, congenital) Homo sapiens
2 CONCLUSIONS: We first demonstrate that hCG prevents apoptosis of granulosa-lutein cells through the induction of Mcl-1 protein via the LH/hCG receptor and a cAMP response element-binding protein-dependent pathway. Cyclic AMP hypertrichosis 2 (generalised, congenital) Homo sapiens