Title : Myostatin down-regulates the IGF-2 expression via ALK-Smad signaling during myogenesis in cattle.

Pub. Date : 2010 Apr

PMID : 20438504






1 Functional Relationships(s)
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1 An activin-like kinase (ALK) inhibitor, SB431542, mediates MSTN action, suppressed the translocation of Smad2/3 into the nucleus in DM-myoblasts, and restored the attenuated IGF-2 mRNA expression and the decreased myotube formation induced by rMSTN in myoblast cultures. 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide myostatin Bos taurus