Title : Detection of IDH1 and IDH2 mutations by fluorescence melting curve analysis as a diagnostic tool for brain biopsies.

Pub. Date : 2010 Jul

PMID : 20431032






2 Functional Relationships(s)
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1 The aim of this study was to develop and evaluate the performance of a novel real-time PCR and post-PCR fluorescence melting curve analysis assay for the detection of IDH1 and IDH2 mutations in routine formalin-fixed, paraffin-embedded tissues of brain biopsies. Paraffin isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens
2 In summary, we report here the real-time PCR/fluorescence melting curve analysis assay that provides rapid and sensitive detection of IDH mutations in formalin-fixed, paraffin-embedded tissues, and is therefore useful as a powerful adjunct diagnostic tool for refining histopathological diagnosis of brain lesions and guiding patient management. Paraffin isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens