Title : Distribution of gefitinib to the brain is limited by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2)-mediated active efflux.

Pub. Date : 2010 Jul

PMID : 20421331






5 Functional Relationships(s)
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1 Distribution of gefitinib to the brain is limited by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2)-mediated active efflux. Gefitinib phosphoglycolate phosphatase Mus musculus
2 In this study, we investigated the influence of P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) on distribution of gefitinib to the central nervous system. Gefitinib phosphoglycolate phosphatase Mus musculus
3 In this study, we investigated the influence of P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) on distribution of gefitinib to the central nervous system. Gefitinib phosphoglycolate phosphatase Mus musculus
4 The B/P ratio after oral administration increased significantly when gefitinib was coadministered with the dual P-gp and BCRP inhibitor elacridar. Gefitinib phosphoglycolate phosphatase Mus musculus
5 These results show that brain distribution of gefitinib is restricted due to active efflux by P-gp and BCRP. Gefitinib phosphoglycolate phosphatase Mus musculus