Pub. Date : 2010 Aug
PMID : 20413726
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In vitro to in vivo comparison of the substrate characteristics of sorafenib tosylate toward P-glycoprotein. | Sorafenib | phosphoglycolate phosphatase | Mus musculus |
| 2 | To evaluate the influence of P-gp on the pharmacokinetics of sorafenib substrate properties for this transporter were investigated. | Sorafenib | phosphoglycolate phosphatase | Mus musculus |
| 3 | In conclusion, sorafenib is highly permeable and a weak P-gp substrate in vitro. | Sorafenib | phosphoglycolate phosphatase | Mus musculus |
| 4 | Because of the high permeability and low P-gp-mediated transport, sorafenib might be able to cross the blood-brain barrier and target tumors within the brain. | Sorafenib | phosphoglycolate phosphatase | Mus musculus |