Title : Cyclooxygenase-1 mediates prostaglandin E(2) elevation and contextual memory impairment in a model of sustained hippocampal interleukin-1beta expression.

Pub. Date : 2010 Jul

PMID : 20412387






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Downstream actions of IL-1beta include production of prostaglandin (PG) E(2) by increasing expression of cyclooxygenase (COX) enzymes and prostaglandin E synthase (PGES) isoforms. Dinoprostone interleukin 1 beta Mus musculus
2 Here, we aimed to elucidate the effects of long-term IL-1beta expression on the PGE(2) synthetic pathway and to determine the effects of PGs on inflammation and memory in our model. Dinoprostone interleukin 1 beta Mus musculus
3 As expected, PGE(2) levels were significantly elevated after IL-1beta up-regulation. Dinoprostone interleukin 1 beta Mus musculus