Title : The safety, tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of RO5068760, an MEK inhibitor, in healthy volunteers: assessment of target suppression.

Pub. Date : 2010 Dec

PMID : 20386016






1 Functional Relationships(s)
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1 RO5068760, a substituted hydantoin, represents a new class of potent, highly selective, non-adenosine triphosphate (ATP)-competitive MEK1/2 inhibitors. Hydantoins mitogen-activated protein kinase kinase 1 Homo sapiens