Title : Redox signaling, alkylation (carbonylation) of conserved cysteines inactivates class I histone deacetylases 1, 2, and 3 and antagonizes their transcriptional repressor function.

Pub. Date : 2010 Jun 4

PMID : 20385560






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We report that alpha,beta-unsaturated carbonyl compounds, e.g. the cyclopentenone prostaglandin, 15-deoxy-Delta12,14-PGJ(2) (15d-PGJ(2)), and 4-hydroxy-2-nonenal (4HNE), alkylate (carbonylate), a subset of class I HDACs including HDAC1, -2, and -3, but not HDAC8. 15d-pgj histone deacetylase 1 Homo sapiens