Title : Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth.

Pub. Date : 2010 Apr 13

PMID : 20385363






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Mechanistically, itraconazole appears to act on the essential Hh pathway component Smoothened (SMO) by a mechanism distinct from that of cyclopamine and other known SMO antagonists, and prevents the ciliary accumulation of SMO normally caused by Hh stimulation. Itraconazole smoothened, frizzled class receptor Homo sapiens
2 Mechanistically, itraconazole appears to act on the essential Hh pathway component Smoothened (SMO) by a mechanism distinct from that of cyclopamine and other known SMO antagonists, and prevents the ciliary accumulation of SMO normally caused by Hh stimulation. Itraconazole smoothened, frizzled class receptor Homo sapiens
3 Mechanistically, itraconazole appears to act on the essential Hh pathway component Smoothened (SMO) by a mechanism distinct from that of cyclopamine and other known SMO antagonists, and prevents the ciliary accumulation of SMO normally caused by Hh stimulation. Itraconazole smoothened, frizzled class receptor Homo sapiens
4 Mechanistically, itraconazole appears to act on the essential Hh pathway component Smoothened (SMO) by a mechanism distinct from that of cyclopamine and other known SMO antagonists, and prevents the ciliary accumulation of SMO normally caused by Hh stimulation. Itraconazole smoothened, frizzled class receptor Homo sapiens