Title : Methamphetamine-induced neuronal protein NAT8L is the NAA biosynthetic enzyme: implications for specialized acetyl coenzyme A metabolism in the CNS.

Pub. Date : 2010 Jun 4

PMID : 20385109






2 Functional Relationships(s)
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Protein Name
Organism
1 A very recent report has identified Nat8l as the gene encoding Asp-NAT and confirmed that the only child diagnosed with a lack of NAA on brain magnetic resonance spectrograms has a 19-bp deletion in this gene. Aspartic Acid N-acetyltransferase 8 like Homo sapiens
2 In studies done concurrently in our laboratory we have demonstrated via cloning, expression, specificity for acetylation of aspartate, responsiveness to methamphetamine treatment, molecular modeling and comparative immunolocalization that NAT8L is the NAA biosynthetic enzyme Asp-NAT. Aspartic Acid N-acetyltransferase 8 like Homo sapiens