Title : Design, synthesis, and preliminary biological evaluation of pyrrolo[3,4-c]quinolin-1-one and oxoisoindoline derivatives as aggrecanase inhibitors.

Pub. Date : 2010 May 3

PMID : 20379990






1 Functional Relationships(s)
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1 The structure-activity relationship analysis of pyrroloquinolinone derivatives 2 a-i suggests that the carboxylate or hydroxamate groups of compounds 2 a,b play a key role in the interaction of these compounds with ADAMTS-5 and -4. pyrroloquinolinone ADAM metallopeptidase with thrombospondin type 1 motif 5 Homo sapiens