Pub. Date : 2010 Apr
PMID : 20371721
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sorafenib induces growth arrest and apoptosis of human glioblastoma cells through the dephosphorylation of signal transducers and activators of transcription 3. | Sorafenib | signal transducer and activator of transcription 3 | Homo sapiens |
| 2 | The effects of sorafenib on these tumor cells were associated with inhibiting phosphorylated signal transducers and activators of transcription 3 (STAT3; Tyr705). | Sorafenib | signal transducer and activator of transcription 3 | Homo sapiens |
| 3 | The effects of sorafenib on these tumor cells were associated with inhibiting phosphorylated signal transducers and activators of transcription 3 (STAT3; Tyr705). | Sorafenib | signal transducer and activator of transcription 3 | Homo sapiens |
| 4 | Expression of a constitutively activated STAT3 mutant partially blocked the effects of sorafenib, consistent with a role for STAT3 inhibition in the response to sorafenib. | Sorafenib | signal transducer and activator of transcription 3 | Homo sapiens |
| 5 | Expression of a constitutively activated STAT3 mutant partially blocked the effects of sorafenib, consistent with a role for STAT3 inhibition in the response to sorafenib. | Sorafenib | signal transducer and activator of transcription 3 | Homo sapiens |
| 6 | Expression of a constitutively activated STAT3 mutant partially blocked the effects of sorafenib, consistent with a role for STAT3 inhibition in the response to sorafenib. | Sorafenib | signal transducer and activator of transcription 3 | Homo sapiens |
| 7 | Sodium vanadate, a general inhibitor of protein tyrosine phosphatases, blocked the inhibition of phosphorylation of STAT3 (Tyr705) induced by sorafenib. | Sorafenib | signal transducer and activator of transcription 3 | Homo sapiens |
| 8 | These data indicate that the inhibition of STAT3 activity by sorafenib involves both the inhibition of upstream kinases (JAK1 and JAK2) of STAT3 and increased phosphatase activity. | Sorafenib | signal transducer and activator of transcription 3 | Homo sapiens |
| 9 | These data indicate that the inhibition of STAT3 activity by sorafenib involves both the inhibition of upstream kinases (JAK1 and JAK2) of STAT3 and increased phosphatase activity. | Sorafenib | signal transducer and activator of transcription 3 | Homo sapiens |
| 10 | Our data suggest that inhibition of STAT3 signaling by sorafenib contributes to growth arrest and induction of apoptosis in glioblastoma cells. | Sorafenib | signal transducer and activator of transcription 3 | Homo sapiens |