Title : Papyriferic acid derivatives as reversal agents of multidrug resistance in cancer cells.

Pub. Date : 2010 Apr 15

PMID : 20363142






1 Functional Relationships(s)
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1 Forty-one derivatives of papyriferic acid were prepared based on our previous finding that methyl papyriferate (3) showed potent reversing effect on cytotoxicity of colchicine against multidrug resistance (MDR) human cancer cells (KB-C2), and evaluated for their cytotoxicity and effect on reversing P-gp-mediated MDR against KB-C2 cells. Colchicine phosphoglycolate phosphatase Homo sapiens