Title : Simvastatin attenuates acrolein-induced mucin production in rats: involvement of the Ras/extracellular signal-regulated kinase pathway.

Pub. Date : 2010 Jun

PMID : 20359552






1 Functional Relationships(s)
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1 In vitro, simvastatin pretreatment attenuated the acrolein-induced significant increase in MUC5AC mucin expression, Ras-GTPase activity and EGFR/ERK phosphorylation. Acrolein mucin 5AC, oligomeric mucus/gel-forming Rattus norvegicus