Title : Effects of thymidine phosphorylase on tumor aggressiveness and 5-fluorouracil sensitivity in cholangiocarcinoma.

Pub. Date : 2010 Apr 7

PMID : 20355241






2 Functional Relationships(s)
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1 siRNA also reduced the ability of TP to resist hypoxia-induced apoptosis, while suppression of TP reduced the sensitivity of KKU-M139 to 5-fluorouracil. Fluorouracil thymidine phosphorylase Homo sapiens
2 CONCLUSION: Inhibition of TP may be beneficial in decreasing angiogenesis-dependent growth and migration of cholangiocarcinoma but may diminish the response to 5-fluorouracil chemotherapy. Fluorouracil thymidine phosphorylase Homo sapiens