Title : Binding of PDZ-RhoGEF to ATP-binding cassette transporter A1 (ABCA1) induces cholesterol efflux through RhoA activation and prevention of transporter degradation.

Pub. Date : 2010 May 21

PMID : 20348106






1 Functional Relationships(s)
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1 Here we show that the Rho guanine nucleotide exchange factors PDZ-RhoGEF and LARG bind to the C terminus of ABCA1 by a PDZ-PDZ interaction and prevent ABCA1 protein degradation by activating RhoA. Guanine Nucleotides Rho guanine nucleotide exchange factor 11 Homo sapiens