Title : Effects of CYP2B6 G516T polymorphisms on plasma efavirenz and nevirapine levels when co-administered with rifampicin in HIV/TB co-infected Thai adults.

Pub. Date : 2010 Mar 26

PMID : 20338069






4 Functional Relationships(s)
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1 BACKGROUND: Cytochrome P450 2B6 (CYP2B6) metabolizes efavirenz and nevirapine, the major core antiretroviral drugs for HIV in Thailand. Nevirapine cytochrome P450 family 2 subfamily B member 6 Homo sapiens
2 BACKGROUND: Cytochrome P450 2B6 (CYP2B6) metabolizes efavirenz and nevirapine, the major core antiretroviral drugs for HIV in Thailand. Nevirapine cytochrome P450 family 2 subfamily B member 6 Homo sapiens
3 The frequencies of GG, GT and TT genotypes of CYP2B6-G516T were 38.46%, 47.69% and 13.85% in efavirenz group and 44.07%, 52.54% and 3.39% in nevirapine group, respectively. Nevirapine cytochrome P450 family 2 subfamily B member 6 Homo sapiens
4 CONCLUSIONS: CYP2B6-TT genotype had impact on plasma efavirenz and nevirapine concentrations, while rifampicin co-administration had only small effects. Nevirapine cytochrome P450 family 2 subfamily B member 6 Homo sapiens