Title : Tyrosine phosphorylation of SHIP promotes its proteasomal degradation.

Pub. Date : 2010 May

PMID : 20304029






2 Functional Relationships(s)
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1 RESULTS: We show herein that BCR-ABL downregulates SHIP, but not SHIP2 or PTEN, and this can be blocked with the Src kinase inhibitor PP2, which inhibits the tyrosine phosphorylation of SHIP, or with the proteasomal inhibitor MG-132. Tyrosine neuropeptide Y receptor Y6 Mus musculus
2 This ubiquitination can be blocked with PP2, consistent with the tyrosine phosphorylation of SHIP acting as a signal for its ubiquitination. Tyrosine neuropeptide Y receptor Y6 Mus musculus