Title : Biphasic kinetics of inositol 1,4,5-trisphosphate accumulation in gastrin-stimulated parietal cells. Effects of pertussis toxin and extracellular calcium.

Pub. Date : 1991 Apr 22

PMID : 2026251






1 Functional Relationships(s)
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1 Gastrin (10 nM) induced a rapid increase in Ins(1,4,5)P3 content which was maximal after 15 s and corresponded to 2-2.5-fold basal level; this Ins(1,4,5)P3 content then decreased within 30 s. After a longer time of gastrin exposure (greater than 1 min), a sustained and unexpected increase in Ins(1,4,5)P3 accumulation was observed which was maximal at 7.5 min (corresponding to 2.3-2.8-fold basal value) and slightly decreased thereafter. ins(1,4, gastrin Homo sapiens