Title : Anti-inflammatory activity of salvianolic acid B in microglia contributes to its neuroprotective effect.

Pub. Date : 2010 Jul

PMID : 20238162






3 Functional Relationships(s)
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1 Our results showed that Sal B significantly reduced the production of nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and reactive oxygen species (ROS) induced by lipopolysaccharide (LPS) treatment in rat primary microglia in a dose-dependent manner. salvianolic acid B interleukin 1 beta Rattus norvegicus
2 Our results showed that Sal B significantly reduced the production of nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and reactive oxygen species (ROS) induced by lipopolysaccharide (LPS) treatment in rat primary microglia in a dose-dependent manner. salvianolic acid B interleukin 1 beta Rattus norvegicus
3 Sal B also suppressed LPS-induced inducible nitric oxide synthase (iNOS), TNF-alpha, and IL-1beta mRNA expression, which was accompanied by inhibiting transcription factor NF-kappaB activation. salvianolic acid B interleukin 1 beta Rattus norvegicus