Title : Inhibition of CRM1-mediated nuclear export of transcription factors by leukemogenic NUP98 fusion proteins.

Pub. Date : 2010 May 21

PMID : 20233715






1 Functional Relationships(s)
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1 In vitro binding assays revealed that NUP98-HOXA9 binds CRM1 through the FG repeat motif in a Ran-GTP-dependent manner similar to but stronger than the interaction between CRM1 and its export substrates. Guanosine Triphosphate RAN, member RAS oncogene family Homo sapiens