Title : Microinjection of IL-1β into the trigeminal transition zone produces bilateral NMDA receptor-dependent orofacial hyperalgesia involving descending circuitry.

Pub. Date : 2009 Jan 1

PMID : 20221418






1 Functional Relationships(s)
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1 Excitotoxic lesions of the rostral ventromedial medulla with ibotenic acid (2 mug) abolished IL-1beta-induced contralateral hyperalgesia, suggesting a contribution of descending facilitatory drive. Ibotenic Acid interleukin 1 beta Homo sapiens