Title : The K+-Cl cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampus.

Pub. Date : 2010 May 1

PMID : 20211979






1 Functional Relationships(s)
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1 Here we show that these [K(+)](o) responses induced by high-frequency stimulation or GABA(A) agonist application are generated by the neuronal K(+)-Cl() cotransporter KCC2 and that the transporter-mediated KCl extrusion is critically dependent on the bicarbonate-driven accumulation of Cl() in pyramidal neurons. gamma-Aminobutyric Acid solute carrier family 12 member 5 Rattus norvegicus