Pub. Date : 2010 Apr 9
PMID : 20211602
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Block of the human ether-a-go-go-related gene (hERG) K+ channel by the antidepressant desipramine. | Desipramine | ETS transcription factor ERG | Homo sapiens |
| 2 | Since blockade of cardiac human ether-a-go-go-related gene (hERG) channels is an important cause of acquired long QT syndrome, we investigated the acute effects of desipramine on hERG channels to determine the electrophysiological basis for its pro-arrhythmic potential. | Desipramine | ETS transcription factor ERG | Homo sapiens |
| 3 | We examined the effects of desipramine on the hERG channels expressed in Xenopus oocytes using two-microelectrode voltage-clamp techniques. | Desipramine | ETS transcription factor ERG | Homo sapiens |
| 4 | Desipramine-induced concentration-dependent decreases in the current amplitude at the end of the voltage steps and hERG tail currents. | Desipramine | ETS transcription factor ERG | Homo sapiens |
| 5 | The IC(50) for desipramine needed to block the hERG current in Xenopus oocytes decreased progressively relative to the degree of depolarization. | Desipramine | ETS transcription factor ERG | Homo sapiens |
| 6 | The S6 domain mutations, Tyr-652 located in the S6 domain of the hERG channel reduced the potency of the channel block by desipramine more than a mutation of Phe-656 in the same region. | Desipramine | ETS transcription factor ERG | Homo sapiens |
| 7 | These results suggest that desipramine is a blocker of the hERG channels, providing a molecular mechanism for the arrhythmogenic side effects during the clinical administration of desipramine. | Desipramine | ETS transcription factor ERG | Homo sapiens |
| 8 | These results suggest that desipramine is a blocker of the hERG channels, providing a molecular mechanism for the arrhythmogenic side effects during the clinical administration of desipramine. | Desipramine | ETS transcription factor ERG | Homo sapiens |