Pub. Date : 2010 Apr 29
PMID : 20208557
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 15-Deoxy-Delta(12,14)-prostaglandin J(2) stabilizes, but functionally inactivates p53 by binding to the cysteine 277 residue. | Cysteine | tumor protein p53 | Homo sapiens |
| 2 | Moreover, by conducting an in vitro [(35)S]-labeled p53 translation assay, we identified cysteine 277 as a putative site of p53 modification by 15d-PGJ(2). | Cysteine | tumor protein p53 | Homo sapiens |
| 3 | Moreover, by conducting an in vitro [(35)S]-labeled p53 translation assay, we identified cysteine 277 as a putative site of p53 modification by 15d-PGJ(2). | Cysteine | tumor protein p53 | Homo sapiens |
| 4 | In conclusion, 15d-PGJ(2) can undergo nucleophilic addition to p53, presumably at the cysteine 277 residue, rendering this tumor suppressor less susceptible to proteasomal degradation. | Cysteine | tumor protein p53 | Homo sapiens |