Title : Polyaminergic agents modulate contextual fear extinction in rats.

Pub. Date : 2010 May

PMID : 20206278






2 Functional Relationships(s)
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1 In the current study, we investigated whether spermidine and polyamine antagonists that selectively block the NR2B subunit at the NMDAr alter the extinction of contextual conditioned fear in male Wistar rats. Polyamines glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus
2 These results suggest that exogenous and endogenous polyamines facilitate the extinction of contextual conditioned fear through activation of NR2B subunit-containing NMDAr in the hippocampus. Polyamines glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus