Title : Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists.

Pub. Date : 2010 Jun

PMID : 20197375






2 Functional Relationships(s)
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1 Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists. clobenpropit glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis
2 This strategy identified several novel modulators of NMDA receptor function, including the histamine H3 receptor antagonists clobenpropit and iodophenpropit, as well as the vanilloid receptor transient receptor potential cation channel, subfamily V, member 1 (TRPV1) antagonist capsazepine. clobenpropit glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis