Title : Involvement of multidrug resistance-associated protein 4 in efflux transport of prostaglandin E(2) across mouse blood-brain barrier and its inhibition by intravenous administration of cephalosporins.

Pub. Date : 2010 Jun

PMID : 20194529






1 Functional Relationships(s)
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1 At the concentration of 20 microM, several drugs, including cefazolin, cefotaxime, ceftriaxone, and ketoprofen, significantly inhibited [(3)H]PGE(2) uptake into MRP4-expressing membrane vesicles. Cefazolin ATP-binding cassette, sub-family C (CFTR/MRP), member 4 Mus musculus