Title : [Mechanism of cardiac hypertrophy via diacylglycerol-sensitive TRPC channels].

Pub. Date : 2010 Mar

PMID : 20190513






3 Functional Relationships(s)
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1 We found that activation of diacylglycerol (DAG)-responsive canonical transient receptor potential (TRPC) subfamily channels (TRPC3 and TRPC6) mediate membrane depolarization induced by G(q) protein-coupled receptor stimulation. Diglycerides transient receptor potential cation channel subfamily C member 3 Homo sapiens
2 We found that activation of diacylglycerol (DAG)-responsive canonical transient receptor potential (TRPC) subfamily channels (TRPC3 and TRPC6) mediate membrane depolarization induced by G(q) protein-coupled receptor stimulation. Diglycerides transient receptor potential cation channel subfamily C member 3 Homo sapiens
3 DAG-mediated membrane depolarization through activation of TRPC3/TRPC6 channels increases the frequency of Ca(2+) spikes, leading to activation of calcineurin-dependent signaling pathways. Diglycerides transient receptor potential cation channel subfamily C member 3 Homo sapiens