Pub. Date : 2010 May
PMID : 20181929
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Induced ATF-2 represses CDK4 transcription through dimerization with JunD inhibiting intestinal epithelial cell growth after polyamine depletion. | Polyamines | activating transcription factor 2 | Homo sapiens |
| 2 | Decreased levels of cellular polyamines increase activating transcription factor (ATF)-2, but the exact role and mechanism of induced ATF-2 in the regulation of intestinal epithelial cell (IEC) growth remain elusive. | Polyamines | activating transcription factor 2 | Homo sapiens |
| 3 | Here, we reported that induced ATF-2 following polyamine depletion repressed CDK4 gene transcription in IECs by increasing formation of the ATF-2/JunD heterodimers. | Polyamines | activating transcription factor 2 | Homo sapiens |
| 4 | Here, we reported that induced ATF-2 following polyamine depletion repressed CDK4 gene transcription in IECs by increasing formation of the ATF-2/JunD heterodimers. | Polyamines | activating transcription factor 2 | Homo sapiens |
| 5 | Polyamine depletion increased ATF-2/JunD complex and inhibited CDK4 transcription as indicated by a decrease in the levels of CDK4-promoter activity and its mRNA. | Polyamines | activating transcription factor 2 | Homo sapiens |
| 6 | ATF-2 silencing not only prevented inhibition of CDK4 transcription in polyamine-deficient cells but also abolished repression of CDK4 expression induced by ectopic JunD overexpression. | Polyamines | activating transcription factor 2 | Homo sapiens |
| 7 | ATF-2 silencing also promoted IEC growth in polyamine-depleted cells. | Polyamines | activating transcription factor 2 | Homo sapiens |
| 8 | These results indicate that induced ATF-2/JunD association following polyamine depletion represses CDK4 transcription, thus contributing to the inhibition of IEC growth. | Polyamines | activating transcription factor 2 | Homo sapiens |