Title : SHIP is required for dendritic cell maturation.

Pub. Date : 2010 Mar 15

PMID : 20154203






2 Functional Relationships(s)
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1 This immature phenotype of SHIP(-/-) DCs could be reversed with the PI3K inhibitors LY294002 and wortmannin, suggesting that SHIP promotes DC maturation by reducing the levels of the PI3K second messenger phosphatidylinositol-3,4,5-trisphosphate. phosphatidylinositol 3,4,5-triphosphate inositol polyphosphate-5-phosphatase D Mus musculus
2 This immature phenotype of SHIP(-/-) DCs could be reversed with the PI3K inhibitors LY294002 and wortmannin, suggesting that SHIP promotes DC maturation by reducing the levels of the PI3K second messenger phosphatidylinositol-3,4,5-trisphosphate. phosphatidylinositol 3,4,5-triphosphate inositol polyphosphate-5-phosphatase D Mus musculus