Pub. Date : 2010 Apr 9
PMID : 20154087
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors. | celastrol | TNF superfamily member 10 | Homo sapiens |
| 2 | Whether celastrol, a triterpene from traditional Chinese medicine, can modulate the anticancer effects of TRAIL, the cytokine that is currently in clinical trial, was investigated. | celastrol | TNF superfamily member 10 | Homo sapiens |
| 3 | As indicated by assays that measure plasma membrane integrity, phosphatidylserine exposure, mitochondrial activity, and activation of caspase-8, caspase-9, and caspase-3, celastrol potentiated the TRAIL-induced apoptosis in human breast cancer cells, and converted TRAIL-resistant cells to TRAIL-sensitive cells. | celastrol | TNF superfamily member 10 | Homo sapiens |
| 4 | As indicated by assays that measure plasma membrane integrity, phosphatidylserine exposure, mitochondrial activity, and activation of caspase-8, caspase-9, and caspase-3, celastrol potentiated the TRAIL-induced apoptosis in human breast cancer cells, and converted TRAIL-resistant cells to TRAIL-sensitive cells. | celastrol | TNF superfamily member 10 | Homo sapiens |
| 5 | As indicated by assays that measure plasma membrane integrity, phosphatidylserine exposure, mitochondrial activity, and activation of caspase-8, caspase-9, and caspase-3, celastrol potentiated the TRAIL-induced apoptosis in human breast cancer cells, and converted TRAIL-resistant cells to TRAIL-sensitive cells. | celastrol | TNF superfamily member 10 | Homo sapiens |
| 6 | In addition, we found that celastrol induced the cell surface expression of both the TRAIL receptors DR4 and DR5. | celastrol | TNF superfamily member 10 | Homo sapiens |
| 7 | Gene silencing of the death receptor abolished the effect of celastrol on TRAIL-induced apoptosis. | celastrol | TNF superfamily member 10 | Homo sapiens |
| 8 | We found that celastrol also induced reactive oxygen species (ROS) generation, and ROS sequestration inhibited celastrol-induced expression of CHOP and DR5, and consequent sensitization to TRAIL. | celastrol | TNF superfamily member 10 | Homo sapiens |
| 9 | Overall, our results demonstrate that celastrol can potentiate the apoptotic effects of TRAIL through down-regulation of cell survival proteins and up-regulation of death receptors via the ROS-mediated up-regulation of CHOP pathway. | celastrol | TNF superfamily member 10 | Homo sapiens |