Pub. Date : 2010 Dec
PMID : 20151201
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | When transgenic PKU mice that constitutively expressed PAH in muscle were given intraperitoneal supplementation with BH(4), this produced (transient) effective clearance of Phe to normal levels. | Phenylalanine | phenylalanine hydroxylase | Mus musculus |
| 2 | In addition, use of an AAV vector containing the genes for PAH, and for two key synthetic enzymes for BH(4), provided substantial and long-lasting correction (more than 1 year) of blood Phe levels when injected into skeletal muscle of PKU mice. | Phenylalanine | phenylalanine hydroxylase | Mus musculus |