Title : Age-related changes in insulin receptor mRNA and protein expression in genetically obese Zucker rats.

Pub. Date : 2010 Apr

PMID : 20149705






1 Functional Relationships(s)
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1 From age two months, the following changes in liver IR protein expression were observed: (1) decreased IR-beta level in whole homogenates, but increased IR-beta levels in endosomal fractions; (2) increased IR-beta tyrosine phosphorylation; and (3) at four months, increased levels of both intact IR-beta (95 kDa) and IR-beta fragments (72 and 52 kDa) in lysosomal fractions, along with decreased stability in vivo of the IR. Tyrosine insulin receptor Rattus norvegicus